Facilitating Complex Trait Analysis via Reduced Complexity Crosses.
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ABSTRACT:
SUBMITTER: Bryant CD
PROVIDER: S-EPMC7365571 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Facilitating Complex Trait Analysis via Reduced Complexity Crosses.
Bryant Camron D CD Smith Desmond J DJ Kantak Kathleen M KM Nowak Thaddeus S TS Williams Robert W RW Damaj M Imad MI Redei Eva E EE Chen Hao H Mulligan Megan K MK
Trends in genetics : TIG 20200529 8
Genetically diverse inbred strains are frequently used in quantitative trait mapping to identify sequence variants underlying trait variation. Poor locus resolution and high genetic complexity impede variant discovery. As a solution, we explore reduced complexity crosses (RCCs) between phenotypically divergent, yet genetically similar, rodent substrains. RCCs accelerate functional variant discovery via decreasing the number of segregating variants by orders of magnitude. The simplified genetic a ...[more]
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