The role of beta-cell dysfunction in early type 1 diabetes.

ABSTRACT:

Purpose of review

Emerging data have suggested that β-cell dysfunction may exacerbate the development and progression of type 1 diabetes (T1D). In this review, we highlight clinical and preclinical studies suggesting a role for β-cell dysfunction during the evolution of T1D and suggest agents that may promote β-cell health in T1D.

Recent findings

Metabolic abnormalities exist years before development of hyperglycemia and exhibit a reproducible pattern reflecting progressive deterioration of β-cell function and increases in β-cell stress and death. Preclinical studies indicate that T1D may be prevented by modification of pathways impacting intrinsic β-cell stress and antigen presentation. Recent findings suggest that differences in metabolic phenotypes and β-cell stress may r

SUBMITTER: Sims EK 

PROVIDER: S-EPMC7365587 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature