Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population.

ABSTRACT: In recent years, the incidence of tuberculosis (TB) has declined worldwide, although this disease still occurs at relatively high rates in Amerindian populations. This suggests that the genetic ancestry of Amerindians may be an important factor in the development of infections, and may account for at least some of the variation in infection rates in the different populations. The present study investigated the potential influence of Amerindian genetic ancestry on susceptibility to tuberculosis in an Amazon population. The study included 280 patients diagnosed with tuberculosis and 138 asymptomatic hospital employees with no history of TB, but who were in contact with bacterially active TB patients. Ancestry analysis was run on a set of 61 Ancestry-Informative Markers to estimate European,

SUBMITTER: Leal DFDVB 

PROVIDER: S-EPMC7365596 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature