Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer.

ABSTRACT:

Background

Cyclin-dependent kinase 12 (CDK12) loss occurs in 3-7% of metastatic prostate cancer patients and is characterized by a genomic instability signature, but the clinical implications of CDK12 loss are not well established.

Objective

To determine the clinical course of patients with CDK12 mutant advanced prostate cancer compared with other genomic subtypes.

Design, setting, and participants

A retrospective analysis of data from three academic medical centers, including 317 patients with advanced prostate cancer and prior next-generation sequencing from tumor tissue (n = 172) or circulating tumor DNA (n = 145), was performed. Forty-six patients had CDK12 mutations; 34 had biallelic CDK12 loss (79%).

Outcome measurements and statistical analysis

Patients

SUBMITTER: Reimers MA 

PROVIDER: S-EPMC7365609 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature