Functional and Structural Integrity of Frontoparietal Connectivity in Traumatic and Anoxic Coma.

ABSTRACT:

Objectives

Recovery from coma might critically depend on the structural and functional integrity of frontoparietal networks. We aimed to measure this integrity in traumatic brain injury and anoxo-ischemic (cardiac arrest) coma patients by using an original multimodal MRI protocol.

Design

Prospective cohort study.

Setting

Three Intensive Critical Care Units affiliated to the University in Toulouse (France).

Patients

We longitudinally recruited 43 coma patients (Glasgow Coma Scale at the admission < 8; 29 cardiac arrest and 14 traumatic brain injury) and 34 age-matched healthy volunteers. Exclusion criteria were disorders of consciousness lasting more than 30 days and focal brain damage within the explored brain regions. Patient assessments were conducted at leas

SUBMITTER: Peran P 

PROVIDER: S-EPMC7365681 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature