Maternal cardiometabolic factors and genetic ancestry influence epigenetic aging of the placenta.

ABSTRACT: Disruption of physiological aging of the placenta can lead to pregnancy complications and increased risk for cardiometabolic diseases during childhood and adulthood. Maternal metabolic and genetic factors need to operate in concert with placental development for optimal pregnancy outcome. However, it is unknown whether maternal cardiometabolic status and genetic ancestry contribute to differences in placental epigenetic age acceleration (PAA). We investigated whether maternal prepregnancy obesity, gestational weight gain (GWG), blood pressure, and genetic ancestry influence PAA. Among 301 pregnant women from 4 race/ethnic groups who provided placenta samples at delivery as part of the National Institute of Child Health and Human Development Fetal Growth Studies, placental DNA methylation a

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC7365741 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature