Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.

ABSTRACT: Type I interferon (IFN) response is commonly recognized as the main signaling activity of STING. Here, we generate the Sting1^S365A/S365A mutant mouse that precisely ablates IFN-dependent activities while preserving IFN-independent activities of STING. Sting^S365A/S365A mice protect against HSV-1 infection, despite lacking the STING-mediated IFN response. This challenges the prevailing view and suggests that STING controls HSV-1 infection through IFN-independent activities. Transcriptomic analysis reveals widespread IFN-independent activities of STING in macrophages and T cells, and STING activities in T cells are predominantly IFN independent. In mouse tumor models, T cells in the tumor experience substantial cell death that is in part mediated by IFN-independent activ

SUBMITTER: Wu J 

PROVIDER: S-EPMC7365768 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature