Microbial Shifts and Shorter Time to Bowel Resection Surgery Associated with C. difficile in Pediatric Crohn's Disease.

ABSTRACT:

Background

Clostridioides difficile infection and colonization are common in pediatric Crohn's disease (CD). Our aims were to test the relationship between C. difficile positivity and bowel resection surgery and to characterize microbial shifts associated with C. difficile carriage and surgery.

Methods

A retrospective single-center study of 75 pediatric CD patients tested for association between C. difficile carriage and bowel resection surgery. A prospective single-center study of 70 CD patients utilized C. difficile testing and shotgun metagenomic sequencing of fecal samples to define microbiota variation stratified by C. difficile carriage or history of surgery.

Results

The rate of bowel resection surgery increased from 21% in those without C. difficile to 67% in t

SUBMITTER: Hellmann J 

PROVIDER: S-EPMC7365806 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature