Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts.

ABSTRACT: Type 2 diabetes is a major risk factor for cardiovascular disease. Given the contribution of platelets to atherothrombosis-which in turn is a major contributor to cardiac events, there may be cause to consider platelet function in management of diabetes. Despite the large body of research concerning the role of platelets in cardiovascular complications of type 2 diabetes, evidence from population-based studies of platelet aggregation in diabetes is limited. Mean Platelet Volume (MPV), a cell trait partially associated with markers of platelet activity, is more commonly available. We investigated the association of metabolic syndrome and diabetes with platelet aggregation to three physiological agonists, ADP, collagen, and epinephrine, in the Framingham Heart Study Offspring cohort. We furt

SUBMITTER: Rodriguez BAT 

PROVIDER: S-EPMC7365849 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature