HIV-2-Infected Macrophages Produce and Accumulate Poorly Infectious Viral Particles.

ABSTRACT: A significant proportion of HIV-2-infected patients exhibit natural virological control that is generally absent from HIV-1-infected patients. Along with CD4⁺ T cells, HIV-1 targets macrophages which may contribute to viral spreading and the latent reservoir. We have studied the relationship between macrophages and HIV-2, focusing on post-entry steps. HIV-2-infected monocyte-derived macrophages (MDMs) produced substantial amounts of viral particles that were largely harbored intracellularly. New viruses assembled at the limiting membrane of internal compartments similar to virus-containing compartments (VCCs) described for HIV-1. VCCs from MDMs infected with either virus shared protein composition and morphology. Strikingly, HIV-2 Gag was mostly absent from the cytosol and almos

SUBMITTER: Gea-Mallorqui E 

PROVIDER: S-EPMC7365954 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature