Arum conophalloides Aqueous Extract Induced Hepatotoxicity in Rat; Histopathological, Biochemical, and mir-122 Assessments.

ABSTRACT:

Background

Arum conophalloides (A. conophalloides) is a wild edible delicate plant, widely used in traditional medicine.

Objective

This study aimed to examine the effects of A. conophalloides extracts on biochemical, molecular, and histopathological changes in the rat.

Methods

Fifty adult male Sprague-Dawley rats were divided into 5 groups (10 each) as follows: G1 or control, received distilled water; G2 and G3, treated with the aqueous extract at doses of 200 and 400 mg/kg; G4 and G5, treated with the hydroalcoholic extract at doses of 200 and 400 mg/kg. Prior to and at the end of the experiments, the serum levels of biochemistry parameters and the relative expression of miR-122 were assessed. Moreover, the liver and kidney tissues were examined microsc

SUBMITTER: Derakhshanfar A 

PROVIDER: S-EPMC7366011 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature