A lung for all: Novel mechanical ventilator for emergency and low-resource settings.

ABSTRACT:

Aims

To create a low-cost ventilator that could be constructed with readily-available hospital equipment for use in emergency or low-resource settings.

Main methods

The novel ventilator consists of an inspiratory limb composed of an elastic flow-inflating bag encased within a non-compliant outer sheath and an expiratory limb composed of a series of two, one-way bidirectional splitter valves derived from a self-inflating bag system. An Arduino Uno microcontroller controls a solenoid valve that can be programmed to open and close to produce a set respiratory rate and inspiratory time. Using an ASL 5000 Lung Simulator, we obtained flow, pressure, and volume waveforms at different lung compliances.

Key findings

At a static lung compliance of 50 mL/cm H₂O and an airway resistance of 6 cm H₂O/L/s, ventilated at a PIP and PEEP of 16 and 5 cm H₂O, respectively, tidal volumes of approximately 540 mL were achieved. At a static lung compliance of 20 mL/cm H₂O and an airway resistance of 6 cm H₂O/L/s, ventilated at a PIP and PEEP of 38 and 15 cm H₂O, respectively, tidal volumes of approximately 495 mL were achieved.

Significance

This novel ventilator is able to safely and reliably ventilate patients with a range of pulmonary disease in a simulated setting. Opportunities exist to utilize our ventilator in emergency situations and low-resource settings.

SUBMITTER: Zuckerberg J 

PROVIDER: S-EPMC7366115 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature