STAT1 inhibits T-cell exhaustion and myeloid derived suppressor cell accumulation to promote antitumor immune responses in head and neck squamous cell carcinoma.

ABSTRACT: Cancers of the oral cavity remain the sixth most diagnosed cancer worldwide, with high rates of recurrence and mortality. We determined the role of STAT1 during oral carcinogenesis using two orthotopic models in mice genetically deficient for Stat1. Metastatic (LY2) and nonmetastatic (B4B8) head and neck squamous cell carcinoma (HNSCC) cell lines were injected into the oral cavity of Stat1 deficient (Stat1^-/- ) and Stat1 competent (Stat1^+/+ ) mice. Stat1^-/- mice displayed increased tumor growth and metastasis compared to Stat1^+/+ mice. Mechanistically, Stat1^-/- mice displayed impaired CD4+ and CD8+ T-cell expansion compared to Stat1^+/+ mice. This was associated with enhanced T-cell exhaustion, and severely attenuated T-cell

SUBMITTER: Ryan N 

PROVIDER: S-EPMC7366342 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature