Lymphovascular Invasion Is Associated With Mutational Burden and PD-L1 in Resected Lung Cancer.

ABSTRACT:

Background

High tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are leading biomarkers in metastatic non-small cell lung cancer (NSCLC) and predict favorable response to checkpoint inhibitors. We sought to identify clinicopathologic characteristics associated with elevated TMB and PD-L1 expression among patients who underwent resection for NSCLC.

Methods

NSCLC patients undergoing primary resection (2016-2018) were prospectively enrolled in an immunogenomic profiling project. Multiplex immunofluorescence quantified densities (cells/mm²) of CD3⁺, CD3⁺CD8⁺, CD3⁺CD8⁺PD-1⁺, malignant cells (MCs), MCsPD-L1⁺, CD68⁺, CD68⁺PD-L1⁺, and

SUBMITTER: Mitchell KG 

PROVIDER: S-EPMC7366360 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature