Gut transcriptomic changes during hibernation in the greater horseshoe bat (Rhinolophus ferrumequinum).

ABSTRACT:

Background

The gut is the major organ for nutrient absorption and immune response in the body of animals. Although effects of fasting on the gut functions have been extensively studied in model animals (e.g. mice), little is known about the response of the gut to fasting in a natural condition (e.g. hibernation). During hibernation, animals endure the long term of fasting and hypothermia.

Results

Here we generated the first gut transcriptome in a wild hibernating bat (Rhinolophus ferrumequinum). We identified 1614 differentially expressed genes (DEGs) during four physiological states (Torpor, Arousal, Winter Active and Summer Active). Gene co-expression network analysis assigns 926 DEGs into six modules associated with Torpor and Arousal. Our results reveal that in re

SUBMITTER: Sun H 

PROVIDER: S-EPMC7366455 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature