Altered ratio of circulating follicular regulatory T cells and follicular helper T cells during primary EBV infection.

ABSTRACT: Follicular help T cells (Tfh) play an important role in the activation and differentiation of B cells, while follicular regulatory T cells (Tfr) control Tfh and resulting humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of Tfr contributed to the pathogenesis of infectious diseases. However, the role of Tfr in Epstein-Barr virus (EBV) infection remains lacking. Fifty-five EBV-infected infectious mononucleosis (IM) patients and 21 healthy individuals (HIs) were recruited in the study. We investigated the number of Tfr (FoxP3⁺CXCR5⁺PD-1⁺CD4⁺) and Tfh (FoxP3^-CXCR5⁺PD-1⁺CD4⁺) of peripheral blood in IM patients at diagnosis (D0) and day 15 after diagnosis (D15) via multi

SUBMITTER: Qian J 

PROVIDER: S-EPMC7366583 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature