Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts

ABSTRACT: The molecular mechanisms involved in the terminal differentiation of erythroblasts have been elucidated by comparing enucleation and cell division. Although various similarities and differences between erythroblast enucleation and cytokinesis have been reported, the mechanisms that control enucleation remain unclear. We previously reported that dynein and microtubule-organizing centers mediated the polarization of nuclei in human erythroblasts. Moreover, the accumulation of F-actin was noted during the enucleation of erythroblasts. Therefore, during enucleation, upstream effectors in the signal transduction pathway regulating dynein or actin, such as cell division control protein 42 homolog (Cdc42), may be crucial. We herein investigated the effects of the Cdc42 inhibitor, CASIN, on cytoki

SUBMITTER: Ubukawa K 

PROVIDER: S-EPMC7366696 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature