STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.

ABSTRACT:

Introduction

A large amount of literature has indicated that excitatory synaptic transmission plays a crucial role in epilepsy, but the detailed pathogenesis still needs to be clarified.

Methods

In the present study, we used samples from patients with temporal lobe epilepsy, pentylenetetrazole-kindled mice, and Mg²⁺ -free-induced epileptic cultured hippocampal neurons to detect the expression pattern of STK24. Then, the whole-cell recording was carried out after STK24 overexpression in the Mg²⁺ -free-induced epileptic cultured hippocampal neurons. In addition, coimmunoprecipitation was performed to detect the association between endogenous STK24 and main subunits of NMDARs and AMPARs in the hippocampus of PTZ-kindled mice.

Results

Here, we report

SUBMITTER: Yang J 

PROVIDER: S-EPMC7366740 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature