RGS16 promotes glioma progression and serves as a prognostic factor.

ABSTRACT:

Background

RGS protein family members have recently became new potentially promising therapeutic targets in many cancers. However, as a key member of RGS family, RGS16 has seldom been studied in glioma. The present study was designed to investigate the prognostic value and biological function of RGS16 based on large-scale databases and functional assays in vitro.

Methods

Here, we performed comprehensive analysis for the expression characteristic of RGS16 in Chinese Glioma Genome Atlas (CGGA) microarray database with 301 patients and validated in The Cancer Genome Atlas (TCGA) microarray and RNA sequencing database. Student's t-test, one-way ANOVA test and long-rank test were used to assess differences between groups. Kaplan-Meier survival, univariate and multivariate Cox ana

SUBMITTER: Huang R 

PROVIDER: S-EPMC7366748 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature