Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium.

ABSTRACT: The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13_rs1295686A/A genotype had an increased risk of AML (P_Corr = 0.0144) whereas carriers of the VEGFA_rs25648T allele had a decreased risk of developing the disease (P_Corr = 0.00086). In addition, we found an association of the IL8_rs2227307 SNP with a decreased risk of developing AML that remained marginally significant after multiple testing (P_Corr = 0.072). Functiona

SUBMITTER: Sanchez-Maldonado JM 

PROVIDER: S-EPMC7366925 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature