Phylogenetic and phylodynamic analyses of SARS-CoV-2.

ABSTRACT: To investigate the evolutionary and epidemiological dynamics of the current COVID-19 outbreak, a total of 112 genomes of SARS-CoV-2 strains sampled from China and 12 other countries with sampling dates between 24 December 2019 and 9 February 2020 were analyzed. We performed phylogenetic, split network, likelihood-mapping, model comparison, and phylodynamic analyses of the genomes. Based on Bayesian time-scaled phylogenetic analysis with the best-fitting combination models, we estimated the time to the most recent common ancestor (TMRCA) and evolutionary rate of SARS-CoV-2 to be 12 November 2019 (95 % BCI: 11 October 2019 and 09 December 2019) and 9.90 × 10^-4 substitutions per site per year (95 % BCI: 6.29 × 10^-4-1.35 × 10^-3), respectively. Notably, the very

SUBMITTER: Nie Q 

PROVIDER: S-EPMC7366979 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature