Ontology highlight
ABSTRACT:
SUBMITTER: Alharbi AS
PROVIDER: S-EPMC7367172 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Alharbi Arwaf S AS Garcin Aurélie J AJ Lennox Kim A KA Pradeloux Solène S Wong Christophe C Straub Sarah S Valentin Roxane R Pépin Geneviève G Li Hong-Mei HM Nold Marcel F MF Nold-Petry Claudia A CA Behlke Mark A MA Gantier Michael P MP
Nucleic acids research 20200701 13
Oligonucleotide-based therapeutics have become a reality, and are set to transform management of many diseases. Nevertheless, the modulatory activities of these molecules on immune responses remain incompletely defined. Here, we show that gene targeting 2'-O-methyl (2'OMe) gapmer antisense oligonucleotides (ASOs) can have opposing activities on Toll-Like Receptors 7 and 8 (TLR7/8), leading to divergent suppression of TLR7 and activation of TLR8, in a sequence-dependent manner. Surprisingly, TLR8 ...[more]