Identification of a three-miRNA signature as a novel prognostic model for papillary renal cell carcinoma.

ABSTRACT:

Background

Papillary renal cell carcinoma (pRCC) accounting for near 20% of renal cell carcinoma is the second most common histological subtype. MiRNAs have been demonstrated to played significant roles on predicting prognosis of patients with tumors. An appropriate and comprehensive miRNAs analysis based on a great deal of pRCC samples from The Cancer Genome Atlas (TCGA) will provide perspective in this field.

Methods

We integrated the expression of mRNAs, miRNAs and the relevant clinical data of 321 pRCC patients recorded in the TCGA database. The survival-related differential expressed miRNAs (sDEmiRs) were estimated by COX regression analysis. The high-risk group and the low-risk group were separated by the median risk score of the risk score model (RSM) based on three s

SUBMITTER: Li G 

PROVIDER: S-EPMC7367267 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature