Identification of potential blood biomarkers for early diagnosis of Alzheimer's disease through RNA sequencing analysis.

ABSTRACT:

Background

With demographic shifts toward older populations, the number of people with dementia is steadily increasing. Alzheimer's disease (AD) is the most common cause of dementia, and no curative treatment is available. The current best strategy is to delay disease progression and to practice early intervention to reduce the number of patients that ultimately develop AD. Therefore, promising novel biomarkers for early diagnosis are urgently required.

Methods

To identify blood-based biomarkers for early diagnosis of AD, we performed RNA sequencing (RNA-seq) analysis of 610 blood samples, representing 271 patients with AD, 91 cognitively normal (CN) adults, and 248 subjects with mild cognitive impairment (MCI). We first estimated cell-type proportions among AD, MCI, and CN

SUBMITTER: Shigemizu D 

PROVIDER: S-EPMC7367375 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature