Network-based identification of biomarkers for colon adenocarcinoma.

ABSTRACT:

Background

As one of the most common cancers with high mortality in the world, we are still facing a huge challenge in the prevention and treatment of colon cancer. With the rapid development of high throughput technologies, new biomarkers identification for colon cancer has been confronted with the new opportunities and challenges.

Methods

We firstly constructed functional networks for each sample of colon adenocarcinoma (COAD) by using a sample-specific network (SSN) method which can construct individual-specific networks based on gene expression profiles of a single sample. The functional genes and interactions were identified from the functional networks, respectively.

Results

Classification and subtyping were used to test the function of the functional genes and

SUBMITTER: Hu F 

PROVIDER: S-EPMC7367377 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature