YYFZBJS ameliorates colorectal cancer progression in Apc^Min/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation.

ABSTRACT:

Background

Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of the main populations of effector immune cells in antitumor immunity, has been considered as a double-edged sword during the progression of CRC. Our previous studies indicate that traditional Chinese herbs (TCM) have potential anticancer effects in improving quality of life and therapeutic effect. However, little is known about the mechanism of TCM formula in cancer prevention.

Methods

Here, we used C57BL/6 J Apc^Min/+ mice, an animal model of human intestinal tumorigenesis, to investigate the gut bacterial diversity and their mechanisms of action i

SUBMITTER: Sui H 

PROVIDER: S-EPMC7367414 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature