Dataset Information
Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma.
Ontology highlight
ABSTRACT: Background/aim
To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC).Materials and methods
We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC.Results
PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival.Conclusion
CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence.
SUBMITTER: Ueda S
PROVIDER: S-EPMC7367605 | biostudies-literature | 2020 Jul-Aug
REPOSITORIES: biostudies-literature
Publications
Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma.
Cancer genomics & proteomics 20200701 4
<h4>Background/aim</h4>To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC).<h4>Materials and methods</h4>We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC.<h4>Results</h4>PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR an ...[more]
