Stromal score as a prognostic factor in primary gastric cancer and close association with tumor immune microenvironment.

ABSTRACT:

Background

Gastric cancer remains one of the major causes for tumor-related deaths worldwide. Our study aimed to provide an understanding of primary gastric cancer and prompt its clinical diagnosis and treatment.

Methods

We integrated the expression profiles and overall survival information of primary gastric cancer in TCGA and GEO database and estimated the stromal score of each sample by the estimate R package. Stromal score and clinicopathologic characteristics associated with overall survival were analyzed by using Cox regression and the Kaplan-Meier method. Gene set enrichment analysis (GSEA) and KEGG analysis were performed to explore the potential molecular mechanism in TCGA dataset. The relationship between immunotherapy-associated markers or immune cell types and st

SUBMITTER: Mao M 

PROVIDER: S-EPMC7367639 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature