Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.

ABSTRACT:

Background

Folate metabolism plays an important role in DNA methylation and nucleic acid synthesis and thus may function as a regulatory factor in cancer development. Genome-wide association studies (GWASs) have identified some single-nucleotide polymorphisms (SNPs) associated with cutaneous melanoma-specific survival (CMSS), but no SNPs were found in genes involved in the folate metabolic pathway.

Objectives

To examine associations between SNPs in folate metabolic pathway genes and CMSS.

Methods

We comprehensively evaluated 2645 (422 genotyped and 2223 imputed) common SNPs in folate metabolic pathway genes from a published GWAS of 858 patients from The University of Texas MD Anderson Cancer Center and performed the validation in another GWAS of 409 patients from the

SUBMITTER: Dai W 

PROVIDER: S-EPMC7367702 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature