On the Differential Roles of Mg²⁺, Zn²⁺, and Cu²⁺ in the Equilibrium of β-N-Methyl-Amino-L-Alanine (BMAA) and its Carbamates.

ABSTRACT: β-N-methyl-amino-L-alanine (BMAA) in the presence of bicarbonate (HCO₃^-) undergoes structural modifications generating two carbamate species, α-carbamate and β-carbamate forms of BMAA. The chemical structure of BMAA and BMAA-carbamate adducts strongly suggest they may interact with divalent metal ions. The ability of BMAA to cross the blood-brain barrier and possibly interact with divalent metal ions may augment the neurotoxicity of these molecules. To understand the effects of divalent metal ions (Mg²⁺, Zn²⁺, and Cu²⁺) on the overall dynamic equilibrium between BMAA and its carbamate adducts, a systematic study using nuclear magnetic resonance (NMR) is presented. The chemical equilibria between BMAA, its carbamate adducts, and each of

SUBMITTER: Diaz-Parga P 

PROVIDER: S-EPMC7367705 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature