Ontology highlight
ABSTRACT:
SUBMITTER: Rubin JD
PROVIDER: S-EPMC7367759 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Rubin Jeffrey D JD Barry Michael A MA
Molecular diagnosis & therapy 20200801 4
Mutations in approximately 80 genes have been implicated as the cause of various genetic kidney diseases. However, gene delivery to kidney cells from the blood is inefficient because of the natural filtering functions of the glomerulus, and research into and development of gene therapy directed toward kidney disease has lagged behind as compared with hepatic, neuromuscular, and ocular gene therapy. This lack of progress is in spite of numerous genetic mouse models of human disease available to t ...[more]