Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression.

ABSTRACT:

Rationale

Regression of atherosclerosis is an important clinical goal; however, the pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques are poorly understood. Regulatory T cells (Tregs) have been shown to be atheroprotective, yet the numbers of these immunosuppressive cells decrease with disease progression, and whether they contribute to atherosclerosis regression is not known.

Objective

We investigated the roles of Tregs in the resolution of atherosclerotic inflammation, tissue remodeling, and plaque contraction during atherosclerosis regression.

Methods and results

Using multiple independent mouse models of atherosclerosis regression, we demonstrate that an increase in plaque Tregs is a common signature of regressing plaques

SUBMITTER: Sharma M 

PROVIDER: S-EPMC7367765 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature