Microbiota modulate sympathetic neurons via a gut-brain circuit.

ABSTRACT: Connections between the gut and brain monitor the intestinal tissue and its microbial and dietary content¹, regulating both physiological intestinal functions such as nutrient absorption and motility^2,3, and brain-wired feeding behaviour². It is therefore plausible that circuits exist to detect gut microorganisms and relay this information to areas of the central nervous system that, in turn, regulate gut physiology⁴. Here we characterize the influence of the microbiota on enteric-associated neurons by combining gnotobiotic mouse models with transcriptomics, circuit-tracing methods and functional manipulations. We find that the gut microbiome modulates gut-extrinsic sympathetic neurons: microbiota depletion leads to increased expression of the ne

SUBMITTER: Muller PA 

PROVIDER: S-EPMC7367767 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature