Expected value and sensitivity to punishment modulate insular cortex activity during risky decision making.

ABSTRACT: The exact contribution of the insula to risky decision making remains unclear, as are the specific outcome parameters and inter-individual characteristics that modulate insular activity prior to a risky choice. This fMRI study examines the contributions of outcome valence, magnitude, probability, and expected value (EV) to insular activity during risky decision making, and explores the influence of sensitivity to reward and to punishment, and anxiety, to insular activity. Participants (N = 31) performed a gambling task requiring choice between two roulettes with different outcome magnitude, probability and EV, under gain and loss conditions separately, and filled questionnaires assessing sensitivity to punishment/reward, and state/trait anxiety. Parametric analyses were conducted to examin

SUBMITTER: Von Siebenthal Z 

PROVIDER: S-EPMC7367818 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature