Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.

ABSTRACT: The schizophrenia-associated gene, BRD1, encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health. Alterations in histone modifications and epigenetic regulation contribute to brain transcriptomic changes in affective disorders and preclinical data supports a role for BRD1 in psychopathology. However, the implication of BRD1 on affective pathology remains poorly understood. In this study, we assess affective behaviors and associated neurobiology in Brd1^+/- mice along with their responses to Fluoxetine and Imipramine. This involves behavioral, neurostructural, and neurochemical characterizations along with regional cerebral gene expression profiling combined with integrative functional genomic analyses. We report behavioral

SUBMITTER: Rajkumar AP 

PROVIDER: S-EPMC7367888 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature