The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.

ABSTRACT: Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is presented. It details all procedures required to allow test information to be usable for integrated hazard assessment, strategic project decisions and/or for regulatory purposes. The EU-ToxRisk project developed a strategy to provide regulatorily valid data, and exemplified this using a panel of > 20 assays (with > 50 individual endpoints), each exposed to 19 well-known test compounds (e.g. rotenone, colchicine, mercury, paracetamol, rifampicine, paraquat, taxol). Examples of strategy implementation are provided for all aspects required to ensure data validity: (i) documenta

SUBMITTER: Krebs A 

PROVIDER: S-EPMC7367925 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature