Long-term Safety of Oral Systemic Therapies for Psoriasis: A Comprehensive Review of the Literature.

ABSTRACT: Oral systemic therapies are important treatment options for patients with moderate-to-severe psoriasis, either as monotherapy or in therapy-recalcitrant cases as combination therapy with phototherapy, other oral systemics or biologics. Long-term treatment is needed to maintain sufficient disease control in psoriasis, but continuous use of systemic treatments is limited by adverse events (AEs) and cumulative toxicity risks. The primary aim of this comprehensive literature review was to examine the long-term safety profiles of oral agents commonly used in the treatment of adults with psoriasis. Searches were conducted in EMBASE and PubMed up to November 2018, and 157 relevant publications were included. Long-term treatment with acitretin could be associated with skeletal toxicity and hepatot

SUBMITTER: Balak DMW 

PROVIDER: S-EPMC7367959 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature