The belated US FDA approval of the adenosine A_2A receptor antagonist istradefylline for treatment of Parkinson's disease.

ABSTRACT: After more than two decades of preclinical and clinical studies, on August 27, 2019, the US Food and Drug Administration (FDA) approved the adenosine A_2A receptor antagonist Nourianz® (istradefylline) developed by Kyowa Hakko Kirin Inc., Japan, as an add-on treatment to levodopa in Parkinson's disease (PD) with "OFF" episodes. This milestone achievement is the culmination of the decade-long clinical studies of the effects of istradefylline in more than 4000 PD patients. Istradefylline is the first non-dopaminergic drug approved by FDA for PD in the last two decades. This approval also provides some important lessons to be remembered, namely, concerning disease-specific adenosine signaling and targeting subpopulation of PD patients. Importantly, this approval paves the way to fos

SUBMITTER: Chen JF 

PROVIDER: S-EPMC7367999 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature