Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.

ABSTRACT: Accumulating evidence suggests that human pluripotent stem cell-derived cardiomyocytes can affect "heart regeneration", replacing injured cardiac scar tissue with concomitant electrical integration. However, electrically coupled graft cardiomyocytes were found to innately induce transient post-transplant ventricular tachycardia in recent large animal model transplantation studies. We hypothesised that these phenomena were derived from alterations in the grafted cardiomyocyte characteristics. In vitro experiments showed that human embryonic stem cell-derived cardiomyocytes (hESC-CMs) contain nodal-like cardiomyocytes that spontaneously contract faster than working-type cardiomyocytes. When transplanted into athymic rat hearts, proliferative capacity was lower for nodal-like than working-typ

SUBMITTER: Ichimura H 

PROVIDER: S-EPMC7368005 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature