Involvement of fine particulate matter exposure with gene expression pathways in breast tumor and adjacent-normal breast tissue.

ABSTRACT:

Background

Fine particulate matter (PM_2.5) has been associated with breast cancer specific mortality, particularly for women with Stage I cancer. We examined the biological pathways that are perturbed by PM_2.5 exposures by analyzing gene expression measurements from breast tissue specimens.

Methods

The Nurses' Health Studies (NHS and NHSII) are prospective cohorts with archival breast tissue specimens from breast cancer cases. Global gene expression data were ascertained with the Affymetrix Glue Human Transcriptome Array 3.0. PM_2.5 was estimated using spatio-temporal models linked to participants' home addresses. All analyses were performed separately in tumor (n = 591) and adjacent-normal (n = 497) samples, and stratified by estrogen recepto

SUBMITTER: DuPre NC 

PROVIDER: S-EPMC7368092 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature