The Increased Ratio of Blood CD56^bright NK to CD56^dim NK Is a Distinguishing Feature of Primary Sjogren's Syndrome.

ABSTRACT:

Objective

The aim of this study was to characterize the subsets of circulating CD56⁺ NK cells in pSS patients and their potential value in the diagnosis and/or prediction of prognosis in patients with pSS.

Methods

We included 52 pSS patients fulfilling the 2002 AECG criteria or 2012 ACR criteria and 20 age- and gender-matched healthy volunteers. The frequency and absolute number of NK cells and CD56 NK cell subsets in peripheral blood samples were detected by flow cytometry. Other laboratory parameters such as the IgG level and complement protein levels were extracted from the clinical system.

Results

Both the frequency and the absolute number of peripheral blood NK cells were reduced in pSS patients compared to healthy controls. The proportion of CD56

SUBMITTER: Ming B 

PROVIDER: S-EPMC7368214 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature