Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine.

ABSTRACT: Despite positive initial outcomes emerging from preclinical and early clinical investigation of alginate hydrogel injection therapy as a treatment for heart failure, the lack of knowledge about the mechanism of action remains a major shortcoming that limits the efficacy of treatment design. To identify the mechanism of action, we examined previously unobtainable measurements of cardiac function from in vivo, ex vivo, and in silico states of clinically relevant heart failure (HF) in large animals. High-resolution ex vivo magnetic resonance imaging and histological data were used along with state-of-the-art subject-specific computational model simulations. Ex vivo data were incorporated in detailed geometric computational models for swine hearts in health (n = 5), ischemic HF (n = 5), and is

SUBMITTER: Sack KL 

PROVIDER: S-EPMC7368390 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature