Benzodiazepine use before conception and risk of ectopic pregnancy.

ABSTRACT:

Study question

Are women who fill a benzodiazepine prescription before conception at increased risk of ectopic pregnancy?

Summary answer

Risk of ectopic pregnancy is 50% higher among women who fill a benzodiazepine prescription before conception.

What is known already

Benzodiazepine use in pregnancy increases the risk of miscarriage, adverse birth outcomes and adverse child development outcomes.

Study design, size, duration

Using data from US commercial insurance claims, we performed a cohort study of 1 691 366 pregnancies between 1 November 2008 and 30 September 2015.

Participants/materials, setting, methods

We identified ectopic pregnancies using diagnosis and procedure codes and used unadjusted and inverse probability of treatment (IPT)-weighted log-b

SUBMITTER: Wall-Wieler E 

PROVIDER: S-EPMC7368395 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature