Testing the twin testosterone transfer hypothesis-intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland.

ABSTRACT:

Study question

Does having a male co-twin influence the female twin's reproductive outcomes?

Summary answer

Women with a male co-twin had the same chances of being pregnant and having children compared to same-sex twin pairs.

What is known already

According to the twin testosterone transfer (TTT) hypothesis, in an opposite-sex twin pregnancy, testosterone transfer from the male to the female co-twin occurs. A large body of literature supports the negative impact of prenatal testosterone exposure on female's reproductive health in animal models; however, evidence from human studies remains controversial.

Study design, size, duration

This cohort study included all dizygotic female twins in the Aberdeen Maternity and Neonatal Databank (Scotland) born before 1 Janu

SUBMITTER: Talia C 

PROVIDER: S-EPMC7368400 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature