Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis.

ABSTRACT: Asthma is a heterogeneous respiratory disease reflecting distinct pathobiologic mechanisms. These mechanisms are based, at least partly, on different genetic factors shared by many other conditions, such as allergic diseases and obesity. Investigating the shared genetic effects enables better understanding of the mechanisms of phenotypic correlations and is less subject to confounding by environmental factors. The increasing availability of large-scale genome-wide association study (GWAS) for asthma has enabled researchers to examine the genetic contributions to the epidemiologic associations between asthma subtypes and those between coexisting diseases and/or traits and asthma. Studies have found not only shared but also distinct genetic components between asthma subtypes, indicating that

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7368660 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature