Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline.

ABSTRACT:

Background

While histopathologic changes correlate with functional impairment in cross-sectional studies of diabetic nephropathy (DN), whether these findings predict future rate of kidney function loss remains uncertain. We thus sought to examine the relationship between kidney histopathology, incidence of end-stage kidney disease (ESKD), and rate of estimated glomerular filtration rate (eGFR) loss in DN.

Methods

In this longitudinal cohort study, we studied 50 adults diagnosed with biopsy-proven DN. We analyzed the histopathologic parameters of each patient's kidney biopsy, as defined by the Renal Pathology Society classification system for DN, and tracked all available eGFR measurements post-biopsy. We additionally collected baseline clinical parameters (at the time of bio

SUBMITTER: Misra PS 

PROVIDER: S-EPMC7368674 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature