Effect of neoadjuvant therapy on breast cancer biomarker profile.

ABSTRACT:

Background

Breast cancer clinical management requires the assessment of hormone receptors (estrogen (ER) and progesterone receptor (PR)), human epidermal growth factor receptor 2 (HER2) and cellular proliferation index Ki67, by immunohistochemistry (IHC), in order to choose and guide therapy according to tumor biology. Many studies have reported contradictory results regarding changes in the biomarker profile after neoadjuvant therapy (NAT). Given its clinical implications for the disease management, we aimed to analyze changes in ER, PR, HER2, and Ki67 expression in paired core-needle biopsies and surgical samples in breast cancer patients that had either been treated or not with NAT.

Methods

We included 139 patients with confirmed diagnosis of invasive ductal breast carcin

SUBMITTER: Rey-Vargas L 

PROVIDER: S-EPMC7368678 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature