Characterization of a multicenter pediatric-hydrocephalus shunt biobank.

ABSTRACT:

Background

Pediatric hydrocephalus is a devastating and costly disease. The mainstay of treatment is still surgical shunting of cerebrospinal fluid (CSF). These shunts fail at a high rate and impose a significant burden on patients, their families and society. The relationship between clinical decision making and shunt failure is poorly understood and multifaceted, but catheter occlusion remains the most frequent cause of shunt complications. In order to investigate factors that affect shunt failure, we have established the Wayne State University (WSU) shunt biobank.

Methods

To date, four hospital centers have contributed various components of failed shunts and CSF from patients diagnosed with hydrocephalus before adulthood. The hardware samples are transported in paraformal

SUBMITTER: Gluski J 

PROVIDER: S-EPMC7368709 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature