Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats.

ABSTRACT:

Background

Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety risks associated with nanotoxicity. Thus, toxicity testing of nanoparticles is essential to assess the relative health risks associated with consumer exposure.

Methods

In this study, we identified the NOAEL (no observed adverse effect level) of the agglomerated/aggregated TiO₂ P25 (approximately 180 nm) administered at repeated doses to Sprague-Dawley (SD) rats for 28 and 90 days. Ten of the 15 animals were necropsied for toxicity evaluation after the repeated-dose 90-day study, and the remaining five animals were allowed to recover for 28 days. The

SUBMITTER: Heo MB 

PROVIDER: S-EPMC7368713 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature