A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation.

ABSTRACT:

Background

X chromosome inactivation (XCI) is the mechanism by which the X-linked gene dosage is adjusted between the sexes. Evidence shows that many sex-specific diseases have their basis in X chromosome biology. While female schizophrenia patients often have a delayed age of disease onset and clinical phenotypes that are different from those of males, it is unknown whether the sex differences in schizophrenia are associated with X-linked gene dosage and the choice of X chromosome silencing in female cells. Previous studies demonstrated that sex chromosome aneuploidies may be related to the pathogeneses of some psychiatric diseases. Here, we examined the changes in skewed XCI in patients with schizophrenia.

Methods

A total of 109 female schizophrenia (SCZ) patients and 80 a

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7368719 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature